Applications

Cancer Management

We are combating cancer by enabling precision cancer management

Cancer is ranked as a leading cause of death affecting billions of patients and families worldwide and was responsible for almost 10 million deaths in 2020.

That is why we want to transform cancer management and reduce cancer deaths by enabling precision medicine and better monitoring. Precision diagnostics enables the doctor to, based on the cancer’s genomic information, select the treatment that is most likely to work. Our unique technology enables sensitive detection of cancer mutations by a simple blood sample.

By sensitive monitoring of the disease, we have a chance to save the life of patients.

Detection of circulating tumor DNA in liquid biopsies

Using our technology, it is possible to detect circulating tumor DNA from a simple blood sample. Due to turnover and cell death, all cancers release small amounts of tumor-specific DNA into the blood and other body fluids as circulating tumor DNA. Multiple publications have proven the SiMSen-Seq technology is able to detect low-frequent circulating tumor DNA robustly and accurately in liquid biopsies.

Compared to tissue biopsy that is the standard in cancer management to retain genetic information of a tumor, a liquid biopsy is:

Safer for the patients

More cost-efficient

Faster

The impact of circulating tumor DNA detection

A liquid biopsy test empowers the physician with genomic information of the tumor. It enables precision medicine to be applied to more patients. In addition, detection of circulating tumor DNA can be used to monitor the effectiveness of treatment and be used for early detection of relapse or detection of minimal residual diseases. By monitoring for mutations known to cause resistance towards treatment, the physician can more accurately change to the next line of treatment.

Detection of circulating tumor DNA

Interesting in evaluating?

Simsen Diagnostics technology for ctDNA is easy to run in any molecular laboratory. Our evaluation kit constructs a sequencing library from eight amplicons inside the gene PIK3CA in a single reaction.

  • Eight amplicons in PIK3CA
  • 99.5% sensitivity at detecting 0.1% VAF*
  • Easy to use

*When loading more than 15ng DNA