EVIdence

 

See what you could detect before you commit a sample.


The published science, the disease-area reviews and the practical guides, each framed around what the data means for your trial, your laboratory and your patients. Start with what matters to your work, then go straight to the source.

Publications icon

Publications

Peer-reviewed papers, each with a plain-language note on what the result means for you and a permanent link to the source.

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Disease areas

Deep reviews by indication, starting with paediatric solid tumours: the evidence, the sensitivity data, and what it lets you do that you currently cannot.

Explore paediatric solid tumours →
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White papers

Practical guides from our scientific team, starting with how to design a ctDNA endpoint into an oncology trial.

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Latest evidence

Start with these three.

A review, a guide and a result. The full, filterable list lives on the Publications page.

Disease area

Paediatric solid tumours: detecting relapse before imaging can.

What ultra-sensitive ctDNA lets paediatric teams do that they currently cannot, with the sensitivity data and evidence behind it.

Read the review →
White paper

Circulating tumour DNA as a biomarker in clinical trials.

For pharma and CRO teams: MRD enrichment, response monitoring and ctDNA endpoints, and how they cut trial size and cost.

Get the white paper →
Peer-reviewed

Nine months of ctDNA lead time over relapse in neuroblastoma.

ctDNA-monitored response to lorlatinib in ALK-driven neuroblastoma. Ek et al., Cancer Research Communications, 2024.

Read on publisher site ↗
Using the evidence

Can't find evidence for your indication?

Tell our scientific team what you are working on and we will point you to the most relevant data, including unpublished work we can share under agreement.

Contact the scientific team →
How is this different from the Publications page?

This hub brings the different kinds of evidence together: papers, disease-area reviews and white papers. Publications is the deeper, fully citable list of peer-reviewed work on its own.

Why do papers link to the publisher rather than a PDF?

Peer-reviewed papers are copyright of the publisher, so we link to the version of record via its DOI, which is permanent and authoritative. Where a paper is open access, we may also offer the PDF.

Which materials can I download straight away?

Our own white papers are hosted here. Some ask for a few details first so we can stay in touch.

Talk to us

Speak to our scientific team.

A real human, in CET/CEST time zone, who has run samples like yours.

inbox@simsendiagnostics.com →